周揚 副研究員
研究方向(xiàng)：抗菌藥物、抗腫瘤藥物、生物傳感凝膠、抗菌水凝膠
周揚，女，1986年5月生，博士，副研究員。2008年獲得中國(guó)藥科大學(xué)藥劑學(xué)學(xué)士學(xué)位，2013年獲得南京大學(xué)生命科學(xué)學(xué)院生物學(xué)博士，2014年至2015年留學(xué)于韓國(guó)蔚山國(guó)立科技大學(xué)（UNIST）開(kāi)展博士後(hòu)工作，同期2014年至2017年在南京大學(xué)生命科學(xué)院從事(shì)藥學(xué)博士後(hòu)工作，2017年加入中國(guó)科學(xué)院甯波工業技術研究院，任副研究員。先先後(hòu)入選甯波市領軍與拔尖人才工程、甯波市高級人才、慈溪市115人才培養工程等，主持甯波市20205重大專項、國(guó)家青年基金、浙江省青年基金、中國(guó)博士後(hòu)面(miàn)上基金，參與國(guó)家科技支撐項目1項、國(guó)家重點研發(fā)計劃1項，并任浙江省科技信息研究院項目評審專家。加入中科院甯波材料所工作以來，重點圍繞“高活性小分子藥物和材料改性”所涉及的重要科學(xué)與技術問題開(kāi)展工作，緻力于通過(guò)化學(xué)方法對(duì)分子結構和材料骨架進(jìn)行精确調控，開(kāi)發(fā)基于靶點結構的高活性抗菌/抗癌藥物分子以及具有生物活性的凝膠材料，滿足凝膠材料力學(xué)性能(néng)調控與生物醫用的多功能(néng)需求。迄今已在Angew. Chem. Int. Ed.、Adv. Funct. Mater、Mater. Horiz.、ACS Appl Mater Interfaces等高水平期刊發(fā)表論文30餘篇，累計被(bèi)引用1500餘次。
工作經(jīng)曆：
2017年11月—至今，中國(guó)科學(xué)院甯波材料技術與工程研究所，副研究員；
2014年1月—2017年11月， 南京大學(xué)生命科學(xué)學(xué)院藥學(xué)專業，博士後(hòu)；
2014年2月—2015年4月，韓國(guó)國(guó)立蔚山科學(xué)技術大學(xué)多維碳材料中心，博士後(hòu)。
教育經(jīng)曆：
2008年9月—2013年6月，南京大學(xué)生命科學(xué)學(xué)院生物學(xué)專業，獲博士學(xué)位；
2004年9月—2008年6月，中國(guó)藥科大學(xué)藥學(xué)院藥劑學(xué)專業，獲學(xué)士學(xué)位。
代表性論著：
(1) Juan Sun*, Ze-Yu Fang, Yi-Nuo Tao, Yi-Heng Zhang, Yao Zhang, Hai-Ya Sun, Yang Zhou*, Yuan-Feng Wu*. Design, synthesis and antitumor activity of FAK/PLK1 dual inhibitors with quinazolinone as the skeleton. Chem. Biodiversity 2023, 20, e202300146.
(2) Juan Sun*, Cui-Ping Zhang, Chong-Hao Chen, Xiao-Meng Guo, Cai-Shi Liu, Yang Zhou*, Fu-Liang Hu*. Design, synthesis and molecular docking of 1,3,4-Oxadiazole-2(3H)-thione derivatives containing 1,4-benzodioxane skeleton as potential FabH inhibitors. Chem. Biodiversity 2023, 20, e202201060.
(3) Shuai-Jun Guo, Hao-Yun Chang, Meng-Jia Xu, Chen-Xu Wang, Hua Wei, Dong-Dong Li, Jing Chen*, Yang Zhou*, Yi Liu*. Co2+-mediated hydrogels with enhanced mechanical properties for flexible sensing. ACS Appl. Polym. Mater. 2022，4，6403-6413.
(4) Yang Zhou, Yin-Qiu Liang, Xin-Yu Wang, Hao-Yun Chang, Su-Pei Hu*, Juan Sun*. Design, synthesis and antibacterial activities of novel amide derivatives bearing dioxygenated rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Chem. Pharm. Bull. 2022, 70, 544-549.
(5) Peng An, Hua Wei, Yan-Sheng Zhang, Yang Zhou, Hua Zhang*, Wen-Feng Li, Bao-Long Niu*, Jing Chen*. A mechanically adaptive “all-sugar” hydrogel for cell-laden injection. Eur. Polym. J. 2022, 174, 111328.
(6) Juan Sun*, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo, Yang Zhou*, Yuan-Feng Wu*. Thiazolidinedione: A privileged scaffold for the development of anticancer agents. Curr. Top. Med. Chem. 2021, 21, 2529-2545.
(7) Hua Wei, Zhen-Wu Wang, Hua Zhang, You-Ju Huang*, Zong-Bao Wang, Yang Zhou, Ben-Bin Xu*, Sami Halila, and Jing Chen*. Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogels for multimode tactical sensing. Chem. Mater. 2021, 33, 6731-6742.
(8) Hua Zhang, Ting Xu, Dong-Dong Li, Tao Cheng, Jing Chen∗, Yang Zhou∗. Gold complexes of bis-indazole-derived N-Heterocyclic carbene: synthesis, structural characterizations, and catalysis. J. Mol. Struct. 2021, 1233, 130043.
(9) Amarachi Rosemary Osi, Hua Zhang, Jing Chen, Yang Zhou, Rong Wang, Jun Fu*, Peter Müller-Buschbaum, Qi Zhong. Three-dimensional-printable thermo/photo-cross-linked methacrylated chitosan−gelatin hydrogel composites for tissue engineering. ACS Appl. Mater. Interfaces 2021, 13, 22902-22913.
(10) Xin-Jie Pei, Hua Zhang, Yang Zhou, Lin-Jie Zhou and Jun Fu∗. Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions. Mater. Horiz. 2020, 7, 1872-1882 (年度傑出論文獎).
(11) Hua Zhang, Yang Cong, Amarachi Rosemary Osi, Yang Zhou, Fang-Cheng Huang, Remo P. Zaccaria, Jing Chen, Rong Wang, and Jun Fu∗. Direct 3D printed biomimetic scaffolds based on hydrogel microparticles for cell spheroid growth. Adv. Funct. Mater. 2020, 30, 1910573.
(12) Hua Zhang, Peng-Gang Ren, Hua Wei, Sami Halila, Amarachi Osi, Yang Zhou*, Zhong Dai, Rong Wang, Jing Chen. Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent. Soft Matter 2020,16, 8647-8654.
(13) Hua Zhang, Peng-Gang Ren, Fan Yang, Jing Chen, Chen-Xu Wang, Yang Zhou, Jun Fu*. Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions. J. Mater. Chem. B 2020, 8, 10549-10558.
(14) Hua Wei, Hua Zhang, Yang Zhou∗, Zong-Bao Wang, Rong Wang, Jing Chen. Understanding of growth mechanism and structure of multilayer thin films via layer-by-layer hydrogen bonded assembly from polymer brushes-grafted surface. Nanosci. Nanotechnol. Lett. 2020, 12, 890-900.
(15) Kun Fang, Rong Wang*, Hua Zhang, Lin-Jie Zhou, Ting Xu, Ying Xiao, Yang Zhou, Guo-Rong Gao, Jing Chen, Donglei Liu*, Fan-Rong Ai, and Jun Fu*. Mechano-responsive, tough, and antibacterial zwitterionic hydrogels with controllable drug Release for wound healing applications. ACS Appl Mater Interfaces 2020, 12, 52307-52318.
(16) Yong Yin†, Yang Zhou†(共同一作), Shao Sha, Xun Wu, She-Feng Wang, Fang Qiao, Zhong-Cheng Song*, Hai-Liang Zhu*. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα. Bioorg. Chem. 2019, 92, 103238.
(17) Xu-Ping Zhang, Tian-Tian Wang, Zeng-Hui Yuan, Yang Zhou∗, Yu-Shun Yang∗, Hai-Liang Zhu∗. A quinoxalinone-derivated fluorescence sensor with optimized solubility for cysteine detection and biological imaging. Dyes Pigments 2019, 171, 10771.
(18) Dan Xu, Ting Xu, Guorong Gao, Ying Xiao, Zongbao Wang, Jing Chen, Yang Zhou, Rong Wang, Jingbo Yin, Jun Fu*. Effect of Solvent-Matrix Interactions on Structures and Mechanical Properties of Micelle-Crosslinked Gels. J Polym Sci Part B Polym Phys 2019, 57, 473-483.
(19) Liu-Fang Wang, Guo-Rong Gao, Yang Zhou, Ting Xu, Jing Chen, Rong Wang, Rui Zhang*, Jun Fu*. Tough, adhensive, self-healable and transparent ionically conductive zwitterionic nanocomposite hydrogels as skin strain. ACS Appl Mater Interfaces 2019, 11, 3506-3515.
(20) Zhen-Wu Wang, Jing Chen, Liu-Fang wang, Guo-Rong Gao, Yang Zhou, Rong Wang, Ting Xu, Jing-Bo Yin*, Jun Fu*. Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels. J Mater Chem B 2019, 7, 24-29.
(21) Yin Luo*†, Yang Zhou† (共同一作), Yan-Hua Song, Guo Chen, Yu-Xiang Wang, Ye Tian, Wei-Wei Fan, Yu-Shun Yang, Tao Cheng, Hai-Liang Zhu. Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity. Bioorg. Med. Chem. Lett. 2018, 28, 3634-3638.
(22) Guo-Rong Gao, Liu-Fang Wang, Yang Cong, Zhen-Wu Wang, Yang Zhou, Rong Wang, Jing Chen, Jun Fu*. Synergistic pH and temperature driven actuation of poly (NIPAM-co-DMAPMA)/clay nanocomposite hydrogel bilayers. ACS Omega 2018, 3, 17914-17921.
(23) Yang Zhou, Yu-Shun Yang, Xiao-Da Song, Liang Lu, Hai-Liang Zhu*. Study of Schiff-Base-Derived with Dioxygenated Rings and Nitrogen heterocycle as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Chem. Pharm. Bull. 2017, 65, 178-185.
(24) Yang Zhou, Yin Luo, Yu-Shun Yang, Liang Lu, Hai-Liang Zhu*. Study of acylhydrazone derivatives with dioxygenated seven-membered ring as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Med. Chem. Commun. 2016, 7, 1980-1987.
(25) Yin Luo†, Yang Zhou† (共同一作), Jie Fu, Hai-Liang Zhu*. 4,5-Dihydropyrazole derivatives containing oxygen-bearing heterocycles as potential telomerase inhibitors with anticancer activity. RSC Adv. 2014, 4, 23904-23913.
(26) Dong-Qi Wang, Sheng Cai, Rong Ben, Yang Zhou, Xing-Wei Li, Jing Zhao, Wei Wei*, Yong Qian*. Direct access to isoindolinone derivatives by palladium-catalyzed C–H activation and isocyanide insertion by using molecular oxygen as the sole Oxidant. Synthesis 2014, 46, 2045-2050.
(27) Yang Zhou, Qing-Jie Liu, Wei-Feng Lv, Qing-Yu Pang, Rong Ben, Yong Qian*, and Jing Zhao*. Indazolin-s-ylidene–N-heterocyclic carbene complexes of rhodium, palladium, and gold: synthesis, characterization, and catalytic hydration of alkynes. Organometallics 2013, 13, 3753-3759.
(28) Yang Zhou, Qian-Ru Du, Jian Sun, Jing-Ran Li, Fei Fang, Dong-Dong Li, Yong Qian, Hai-Bin Gong*, Jing Zhao, and Hai-Liang Zhu*. Novel schiff-base-derived FabH Inhibitors with dioxygenated rings as antibiotic agents. ChemMedChem 2013, 8, 433-441.
(29) Peng-Cheng Lv, Huan-Qiu Li, Juan Sun, Yang Zhou, Hai-Liang Zhu*. Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents. Bioorg. Med. Chem. 2010, 18, 4606-4614.
(30) Kui Cheng, Qing-Zhong Zheng, Jin Hou, Yang Zhou, Chang-Hong Liu*, Jing Zhao*, Hai-Liang Zhu*. Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorg. Med. Chem. 2010, 18, 2447-2455.
(31) Ying Yang, Lei Shi, Yang Zhou, Huan-Qiu Li, Zhen-Wei Zhu, Hai-Liang Zhu*. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg. Med. Chem. Lett. 2010, 20, 6653-6656.
(32) Yin Luo, Huan-Qiu Li, Yang Zhou, Zi-Lin Li, Tao Yan, and Hai-Liang Zhu*. Metronidazole-deoxybenzoin derivatives as anti-helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8. ChemMedChem 2010, 5, 1110-1116.
(33) Yang Zhou, Jing Zhao*, and Lei Liu*. Meta-selective transition metal catalyzed arene C-H bond functionalization. Angew. Chem. Int. Ed. 2009, 48, 7126-7128.
(34) Qing-Fu Zeng*, Jie Fu, Yang Zhou, Yin-Tao Shi, Hai-Liang Zhu*. Photooxidation degradation of reactive brilliant red K-2BP in aqueous solution by ultraviolet radiation/sodium hypochlorite. Clean-Soil Air Water 2009, 37, 574-580.