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李娟 研究員 博士生導師
日期：2022-04-01， 查看：37494


 

2000.10-2004.07 沈陽藥科大學(xué)藥物化學(xué)專業，獲工學(xué)學(xué)士學(xué)位.
2004.09-2007.07 沈陽藥科大學(xué)藥物分析專業，獲理學(xué)碩士學(xué)位
2008.11-2012.09 德國(guó)馬普生物控制所/德國(guó)圖賓根大學(xué)藥學(xué)專業，獲博士學(xué)位
2012.10-2014.09 中國(guó)科學(xué)院甯波材料技術與工程研究所，博士後(hòu)/助理研究員
2014.12-2018.11 中國(guó)科學(xué)院甯波材料技術與工程研究所，副研究員
2018.12-2020.11 中國(guó)科學(xué)院甯波材料技術與工程研究所，項目研究員
2020.12-至今 中國(guó)科學(xué)院甯波材料技術與工程研究所，研究員

主要從事(shì)神經(jīng)肽生物材料設計與應用研究，曾主持國(guó)家自然科學(xué)基金5項（優青、面(miàn)上、國(guó)際合作等）、科技部重點研發(fā)計劃“診療裝備與生物醫用材料”青年科學(xué)家項目；參與國(guó)家重點研發(fā)計劃“精準醫學(xué)研究”專項、浙江省重點研發(fā)計劃、中科院重點部署等項目。以第一作者或通訊作者在Adv Mater、ACS Nano、Nano Today、Biomaterials等國(guó)際期刊發(fā)表論文50餘篇，申請國(guó)内外發(fā)明專利54項（含PCT專利3項），授權12項（瑞士1項，中國(guó)11項），受邀參加國(guó)内外學(xué)術會議并作邀請報告和分會主持20次。英國(guó)皇家化學(xué)會JMCB期刊新銳科學(xué)家、中科院青促會優秀會員、榮獲甯波市青年科技獎等。目前是國(guó)際神經(jīng)科學(xué)協會會員、中國(guó)抗癌協會納米腫瘤專業委員會委員/青委會副主委、中國(guó)超聲醫學(xué)工程學(xué)會超聲治療及生物學(xué)效應專業委員會委員、中國(guó)醫藥生物技術協會生物醫學(xué)成(chéng)像技術分會委員等。

研究方向(xiàng)：1. 納米生物材料在腫瘤及神經(jīng)系統的成(chéng)像與治療研究
                 2. 多肽及小分子配體藥物設計與應用研究
                 3. 近紅外熒光分子探針設計與應用研究

聯系方式：E-mail：lij@nimte.ac.cn

發(fā)表文章：

  1. Xiaolin Duan, Pin Wang, Lulu He, Zhen He, Shiwei Wang, Fang Yang, Changyong Gao, Wenzhi Ren, Jie Lin, Tianxiang Chen, Chen Xu, Juan Li(*) and Aiguo Wu(*), Peptide-Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy, Advanced Materials 2024, 2311548.
  2. Yi Cao, Xiaojiao Ge, Xueli Zhu, Yingying Han, Pin Wang, Ozioma Udochukwu Akakuru, Aiguo Wu(*), Juan Li(*), Transformable neuropeptide prodrug with tumor microenvironment responsiveness for tumor growth and metastasis inhibition of triple‐negative breast cancer, Advanced Science, 2023, 2300545.
  3. Yuanbo Pan, Yang Zhu, Canxin Xu, Chunshu Pan, Yu Shi, Jianhua Zou, Yanying Li, Xueyin Hu, Bo Zhou, Chenyang Zhao, Qianqian Gao, Jianmin Zhang (*), Aiguo Wu (*), Xiaoyuan Chen (*), and Juan Li (*), Biomimetic Yolk–Shell Nanocatalysts for Activatable Dual-Modal-Image-Guided Triple-Augmented Chemodynamic Therapy of Cancer, ACS Nano 2022, 16：19038-19052.
  4. Yanying Li, Yuanbo Pan, Yinjie Wang, Zhenqi Jiang, Ozioma U. Akakuru, Mingli Li, Xianyun Zhang, Bo Yuan, Jie Xing, Lijia Luo, Dan Larhammar, Aiguo Wu, Juan Li (*); A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma, Nano Today, 2022, 44: 101465.
  5. Yanying Li, Xuelu He, Pin Wang, Bo Yuan, Yuanbo Pan, Xueyin Hu, Liheng Lu, Aiguo Wu(*), Juan Li(*), A D-Y Shaped Neuropeptide Y Mimetic Peptide-Dye Self-Assembly with Maximal Emission Beyond 1300 nm and Glioma Mitochondrial Activity Modulation, Small, 2023, 2308621：1-7.
  6. Lulu He, Le Wang, Zhen He, Cheng Heng Pang, Bencan Tang, Aiguo Wu(*), Juan Li(*), Strategies for utilizing covalent organic frameworks as host materials for the integration and delivery of bioactives, Materials Horizons, 2024, 11, 1126–1151.
  7. Xuelu He, Yuan Luo, Yanying Li, Yuanbo Pan, Ryan T. K. Kwok, Lulu He, Xiaolin Duan, Pengfei Zhang(*), AiguoWu(*), Ben Zhong Tan(*), Juan Li(*), D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-II fluorescence imaging-guided through-skull photodynamic therapy of gliomas, Aggregate, 2023, e396：1-11.    
  8. Yuanbo Pan (#), Canxin Xu (#), Hongzhang Deng, Qing You, Chenyang Zhao, Yanying Li, Qianqian Gao, Ozioma Udochukwu Akakuru, Juan Li (*), Jianmin Zhang(*), Aiguo Wu(*), Xiaoyuan Chen(*); Localized NIR-II laser mediated chemodynamic therapy of glioblastoma, Nano Today, 2022, 43: 101435.
  9. Xiaojiao Ge, Yi Cao, Xueli Zhu, Bo Yuan, Lulu He, Aiguo Wu(*), Juan Li(*), Self-Assembly of Organelle-Localized Neuropeptides Triggers Intrinsic Apoptosis Against Breast Cancer, Advanced Healthcare Materials, 2023, 12：2300265.
  10. Canxin Xu, Yuanbo Pan, Hongchi Zhang, Yuhao Sun, Yi Cao, Pengfei Qi, Mingli Li, Ozioma Udochukwu Akakuru, Lulu He, Chen Xiao, Bomin Sun, Liuguan Bian(*), Juan Li(*), Aiguo Wu(*), Platelet-Membrane-Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhag, Advanced Healthcare Materials, 2023, 12：2300797.
  11. Wenhao Lv (#), Chen Xu (#), Hao Wu, Yangyang Zhu, Ozioma Udochukwu Akakuru, Hui Du, Fang Nie(*), Aiguo Wu(*), Juan Li(*); Ultrasound-visualized nanocarriers with siRNA for targeted inhibition of M2-like TAM polarization to enhance photothermal therapy in NSCLC, Nano Research, 2023, 16: 882-893.
  12. Zhenqi Jiang(#), Xiao Han(#), Yang Du(#), Yanying Li, Yong Li, Juan Li (*), Jie Tian, (*) and Aiguo Wu (*), Mixed Metal Metal–Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging, Nano Letters, 2021, 21, 2730-2737.
  13. Zhenqi Jiang, Bo Yuan, Yinjie Wang, Zhenni Wei, Shan Sun, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*), Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy, Nano Today, 2020, 34: 100910.
  14. Ozioma Udochukwu Akakuru, Chuang Liu, M. Zubair Iqbal (*), Gohar Ijaz Dar, Gao Yang, Kun Qian, Elvis Ikechukwu Nosike, Jie Xing, Zhoujing Zhang, Yanying Li, Juan Li (*) and Aiguo Wu (*), A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors, Small, 2020, 2002445.
  15. Zhenqi Jiang (#), Yinjie Wang (#), Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li (*), Aiguo Wu (*), Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197: 41-50.
  16. Zhenqi Jiang (#), Yuchen Tian (#), Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Jian Yang, Juan Li (*), Aiguo Wu (*), pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time, Biomaterials, 2018, 170: 70-81.
  17. Juan Li (#), Yuchen Tian (#), Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang and Aiguo Wu (*). Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017, 116: 106-117.
  18. Yinjie Wang (#), Yi Cao (#), Zhenqi Jiang, Yanying Li, Bo Yuan, Jie Xing, Mingli Li, Qianqian Gao, Kaiwei Xu, Ozioma Udochukwu Akakuru, Aiguo Wu (*), Juan Li (*); The neuropeptide Y1 receptor ligand-modified cell membrane promotes targeted photodynamic therapy of zeolitic imidazolate frameworks for breast cancer, The Journal of Physical Chemistry Letters, 2021, 46: 11280-11287.
  19. Xuelu He (#), Zhenqi Jiang (#), Ozioma Udochukwu Akakuru, Juan Li (*), Aiguo Wu (*); Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy, Chemical Communications, 2021, 57: 12417-12435.
  20. Zhenqi Jiang (#), Bo Yuan (#), Nianxiang Qiu, Yinjie Wang, Li Sun, Zhenni Wei, Yanyin Li, Jianjun Zheng, Yinhua Jin, Yong Li, Shiyu Du, Juan Li (*), Aiguo Wu (*), Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy, Nano-Micro Letters, 2019, 11, 61.
  21. Zhenqi Jiang, Yanying Li, Zhenni Wei, Bo Yuan, Yinjie Wang, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*). Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo. Bioactive Materials, 2021, 6: 740-748.
  22. Juan Li (#), Yang Du (#), Zhenqi Jiang, Yuchen Tian, Nianxiang Qiu, Yinjie Wang, Muhammad Zubair lqbal, Menying Hu, Ruifen Zou, Lijia Luo, Shiyu Du, Jie Tian (*), Aiguo Wu (*), Y1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy, Nanoscale, 2018, 10: 5845-5851.  
  23. Zhangsen Yu, Yuanzhi Xia, Jie Xing, Zihou Li, Jianjun Zhen, Yinhua Jin, Yuchen Tian, Chuang Liu, Zhenqi Jiang, Juan Li (*), Aiguo Wu (*), Y1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor targeted trimodality imaging and photodynamic therapy with low toxicity, Nanoscale, 2018, 10: 17038-17052.
  24. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu (*). Neuropeptide Y Y1 receptors meditate targeted delivery of anticancer drug with encapsulated nanoparticles to breast cancer cells with high selectivity and its potential for breast cancer therapy. ACS Applied Materials & Interfaces, 2015, 7: 5574-5582.
  25. Yinjie Wang (#), Zhenqi Jiang (#), Bo Yuan, YuchenTian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li (*), Aiguo Wu (*). Y1 receptor ligand synergized with P-glycoprotein inhibitor improves therapeutic efficacy of multidrug resistant breast cancer. Biomaterials Science, 2019, 7: 4748-4757.
  26. Xuechen Qian (#), Yinjie Wang (#), Youfeng Xu, Ling Ma, Nianyu Xue, Zhenqi Jiang, Yi Cao, Ozioma Udochukwu Akakuru, Juan Li (*), Shengmin Zhang (*) and Aiguo Wu (*), Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer, Journal of Materials Chemistry B, 2020, 8: 6837.
  27. Linzi Chen (#), Zhenqi Jiang (#), Ozioma Udochukwu Akakuru, Lifei Yang, Juan Li (*), Suya Ma (*), Aiguo Wu (*), Recent progress in the detection and treatment of atherosclerosis by nanoparticles, Materials Today Chemistry, 2020, 17: 100280.
  28. Juan Li (*), Yuchen Tian, Aiguo Wu (*)，Neuropeptide Y receptors: a promising target for cancer imaging and therapy, Regenerative Biomaterials, 2015, 2: 215-219.

授權與申請專利：

  1. 瑞士專利，李娟，吳愛國(guó)，主動靶向(xiàng)型抗腫瘤藥物及其制備方法，授權，CH 710 313 B1
  2. 中國(guó)專利，李娟，吳愛國(guó)，田宇辰，主動靶向(xiàng)型抗腦腫瘤藥物及其制備方法，授權，ZL201510535764.5
  3. 中國(guó)專利，李娟，吳愛國(guó)，主動靶向(xiàng)型抗腫瘤藥物及其制備方法，授權，ZL201310407938.0
  4. 中國(guó)專利，李娟，蔣振奇，吳愛國(guó)，王胤傑，袁博，房倩蘭，李彥瑩，一種(zhǒng)抗癌藥物複合物及其制備方法和應用，授權，ZL 201711209793.8
  5. 中國(guó)專利，沈折玉，吳愛國(guó)，馬雪華，龔安，任文智，李娟，靶向(xiàng)型診療聯用藥物及其制備方法和應用，授權，ZL 201310318107.6
  6. 中國(guó)專利，李娟，田宇辰，吳愛國(guó), 一種(zhǒng)主動靶向(xiàng)型超聲/熒光雙模态造影劑及其制備方法和應用，授權，ZL201610235965.8
  7. 中國(guó)專利，吳愛國(guó)，蔣振奇，袁博，李娟, 一種(zhǒng)七甲川硝基吲哚花菁染料以及該染料的制備方法和用途，授權，ZL201910175647.0
  8. 中國(guó)專利，吳愛國(guó)，蔣振奇，李娟，王胤傑，袁博，項靈超，李彥瑩, 沸石咪唑框架結構材料的制備方法，授權，ZL201810007681.2
  9. 美國(guó)專利，李娟，吳愛國(guó)，主動靶向(xiàng)型抗腫瘤藥物及其制備方法，申請，14/917,256
  10. 德國(guó)專利，李娟，吳愛國(guó)，主動靶向(xiàng)型抗腫瘤藥物及其制備方法，申請，112014004133.5
  11. 中國(guó)專利，李娟，吳愛國(guó)，主動靶向(xiàng)型抗腫瘤藥物及其制備方法，申請，PCT/CN2014/075727

主持和參與項目：

  1. 國(guó)家科技部重點研發(fā)計劃“診療裝備與生物醫用材料”青年科學(xué)家項目，2023.11-2026.10，200萬元，在研，主持
  2. 國(guó)家自然科學(xué)基金優秀青年基金，2023.01-2025.01，200萬元，在研，主持
  3. 國(guó)家自然科學(xué)基金面(miàn)上項目，2019.01-2022.12，結題，項目負責人
  4. 國(guó)家自然科學(xué)基金委員會與瑞典科研與教育國(guó)際合作基金會合作交流項目，2020.07-2023.06，在研，項目負責人
  5. 國(guó)家自然科學(xué)基金委員會-廣東省政府聯合基金超級計算科學(xué)應用研究專項，2016.01-2017.12，結題，項目負責人
  6. 國(guó)家自然科學(xué)基金青年基金，2013.01-2016.12，結題，項目負責人
  7. 甯波市2025重大專項，2021.07-2024.07，在研，項目負責人
  8. 國(guó)家重點研發(fā)計劃“精準醫學(xué)專項”，2018.07-2020.12，結題，項目骨幹
  9. 浙江省重點研發(fā)計劃，2020.01-2023.12，在研，項目骨幹
  10. 浙江省公益技術應用研究項目，2016.01-2018.12，結題，項目負責人